To determine which topical pharmaceutical products marketed in Belgium contain fragrances and to examine the nature of the fragrance allergens in specific pharmaceutical products having caused iatrogenic contact dermatitis.  

All topical pharmaceutical products marketed in Belgium, which is 3820 products, were examined as to their fragrance content as labelled. Data of 18, 960 patients investigated for contact allergy between 1978 and 2008 were retrieved from our database, including information on the nature of the topical pharmaceutical products used, the results of patch tests, and the sensitization sources.  

Three hundred and seventy (10%) of 3280 of the topical pharmaceutical products were found to contain a total of 66 fragrance substances. Among 3378 patients suffering from iatrogenic allergic contact dermatitis, 127 were found to react to 48 specific products, for which 38 different fragrance substances gave relevant positive reactions. Women were more affected than men, and legs, hands, and face were the most commonly affected body sites.  

Fragrances, the presence of which is in most cases unnecessary, do contribute to iatrogenic allergic contact dermatitis. Moreover, sensitized patients have difficulties in avoiding their specific allergens because standardized labelling of the ingredients in pharmaceutical products is lacking. 

Reference: Nardelli A, D’Hooghe E, Drieghe J, Dooms M, Goossens A., Allergic contact dermatitis from fragrance components in specific topical pharmaceutical products in Belgium, Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium, Contact Dermatitis. 2009 Jun; 60(6):303-13.

This entry was posted on Monday, June 08th, 2009 and is filed under Allergies, Clinical Diagnostics, Perfume, Fragrance. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response or Trackback from your own site.