Indigenous people, diabetes and the burden of pollution

Diabetes is now widely regarded as the 21st century epidemic. With some 284 million people currently diagnosed with the disease, it’s certainly no exaggeration-least of all for Indigenous people.

According to the State of the World’s Indigenous Peoples Report by the United Nations, more than 50 per cent of Indigenous adults over the age of 35 have Type 2 Diabetes, “and these numbers are predicted to rise.”

Diabetes is referred to as a “lifestyle disease,” its rampant spread believed to be caused by obesity due to our increased reliance on the western diet (also known as the “meat-sweet” diet) and our avoidance of regular exercise.

While these may certainly be contributing factors, there is growing evidence that diabetes is closely linked with our environment. More than a dozen studies have been published that show a connection between Persistent Organic Pollutants (POPs) including polychlorinated biphenyls (PCBs); carcinogenic hydrocarbons known as Dioxins; and the “violently deadly” synthetic pesticide, DDT and higher rates of the disease.

“If it is the POPs, not the obesity that causes diabetes, this is really striking if true,” says Dr. David O. Carpenter, director of the Institute for Health and the Environment at the University of Albany.

One out of four Indigenous adults living on reserves in Canada have been diagnosed with Type 2 Diabetes, the most common form of diabetes. The prevalence of the disease appears to be so great that the number of new cases being diagnosed in Canada may exceed the growth of the Indigenous population. It’s no longer uncommon to find children as young as three with the disease. According to government statistics, 27 per cent of all Indigenous people in Canada will have Type 2 Diabetes in the next ten years.

Sandy Lake First Nation, in the Sioux Lookout Zone of northern Ontario, has all but met the mark. A March 2009 study co-authored by Dr. Stewart Harris found that 26 per cent of the community has the disease, the highest recorded rate of diabetes in Canada. With a population of 2,500, the northern Cree community was recently described as an “epicentre” of the epidemic.

There has been little research on the levels of persistent organic pollutants in Sandy Lake; however, according to the First Nations Environmental Health Innovation Network, several neighboring communities who also have high rates of diabetes, like Kitchenuhmaykoosib Inninuwug First Nation, are known to have elevated levels of PCBs in their blood.

The Mohawk community of Akwesasne has its own conflict with diabetes and exposure to POPs. Located across the New York-Ontario-Quebec borders along the St. Lawrence River, three aluminum foundries upriver from the reserve dumped PCBs into the river for decades, contaminating the water, soil, and vegetation.

For many years, Dr. Carpenter has been involved in the study of Adult Mohawks at Akwesasne. Most recently, in 2007, he took part in a study to examine the diabetes/pollution link in the community.

“Our study of adult Mohawks showed a striking elevation in rates of diabetes in relation to blood levels of three persistent organic pollutants, DDE, the metabolite of DDT, hexachlorobenzene and PCBs,” Dr. Carpenter explains. “Our results are quite compatible with those of Lee et al.”

In 2006, Dr. Dae-Hee Lee and her colleagues showed that people with the highest rate of exposure to POPs were roughly 38 times more likely to have diabetes than those with the lowest rate of exposure. Further, “they showed that people who were obese but did not have high levels of POPs were not at increased risk of developing diabetes,” continues Dr. Carpenter. “Probably the reason most people get obese is that they eat too many animal fats, and this is where the POPs are.”

The dietary source of POPs was confirmed by the US Environmental Protection Agency in their Draft 1994 Dioxin Reassessment, which has never been formally released to the public. According to the Draft Reassessment, 93 per cent of our exposure to Dioxin comes from the consumption of beef, dairy, milk, chicken, pork, fish, and eggs; in other words, the western diet.

A May 2001 study published in the Journal of Toxicology and Environmental Health drew similar conclusions to the EPA Reassessment. In addition, the study found that “nursing infants have a far higher intake of dioxins relative to body weight than do all older age groups,” and that human breast milk was twice as toxic dairy milk. It also found that vegans had the overall lowest rate of POPs in their bodies.

According to an October 2009 paper by the Research Centre for Environmental Chemistry and Ecotoxicology at Masaryk University, another major source of POPs, specifically DDT, is the world’s oceans. The paper also found that despite restrictions placed on the use of DDT more than 30 years ago, concentrations of the toxin are on the rise.

Indigenous people carry an unequally high proportion of this global toxic burden. For instance, according to Environment Canada’s National Pollutant Release Inventory (NPRI) there are 212 Indigenous communities in Canada living near or downstream from pulp mills and other facilities that produce dioxins and furans. One striking example is the old Dryden pulp mill near Grassy Narrows which, according to the Grassy Narrows and Islington Bands Mercury Disability Board, dumped tonnes of dioxin-laced mercury wastewater into the English-Wabigoon River system from 1962-70.

Forty years later, the poisonous waste continues to pose a “serious health threat” to Grassy Narrows and the Wabaseemoong First Nations, says the Disability Board. No formal steps have been taken toward remediation by federal or provincial governments.

The Tohono O’odham Nation’s experience bears a close resemblance to Grassy Narrows: the world’s highest rate of diabetes can be found in the southwest Arizona nation. According to Tribal health officials, nearly 70 per cent of the population of 28,000 has been diagnosed with the illness. The O’odham People make up the second largest Indigenous Nation in the United States.

Lori Riddle is a member of Aquimel O’odham Community and founder of the Gila River Alliance for a Clean Environment (GRACE).

GRACE was instrumental in the 10 year struggle against a hazardous waste recycling plant that operated without full permits on O’odham land for decades. Owned by Romic Environmental Technologies Corporation, the plant continuously spewed effluents into the air until it was finally shut down in 2007.

The Romic plant was not the first contributor to the O’odham’s toxic burden, explained Riddle. Looking back to her childhood, she recalled: “For nearly a year, [when] a plane would go over our heads, you could see the mist. We never thought to cover our water. The chemicals just took over and they became a part of us.”

From the early 1950s until the late 60s, cotton farmers in the Gila River watershed routinely sprayed DDT onto their crops to protect them from bollworms. According to the Agency of Toxic Substances and Disease Registry (ATSDR), each and every year, the farmers used roughly Twenty-three pounds of DDT per acre.

In 1969, the State of Arizona banned the use of DDT; by this time the river was gravely contaminated. According to the ATSDR, farmers then switched to Toxaphene, a substitute for DDT-until it was banned by the US government in 1990.

Because of these chemicals, Riddle explains, the O’odham were forced to abandon their traditional foods and adopt a western diet. Farms also went into a recession, forcing many families to leave their communities. Companies, such as Romic, began moving on to their territory, exasperating the situation. “It’s taken a toll on our quality of life,” she says. “I’ve cried myself to sleep.”

The O’odham are dealing with what Riddle terms “cluster symptoms” including miscarriages, arthritis in the spine, breathing problems, unexplainable skin rashes, and problems regenerating blood cells. This in addition to diabetes, which frequently leads to renal failure, blindness, heart disease, and amputations.

More and more studies are being published that show the link between diabetes and persistent organic pollutants like DDT-stemming from the landmark “Ranch Hand” study. In 1998, the study found a 166 per cent increase in diabetes (requiring insulin control) in US Air Force personnel who were sprayed with the herbicide and defoliant Agent Orange during the Vietnam War. The study also found that as dioxin levels increased so did the presence and severity of Type 2 diabetes, the time to onset declined following a similar trend.

However, Dr. Carpenter notes that because of the widely-endorsed belief that diabetes is a life-style disease related to diet and exercise, the link is gaining little attention by governments, news agencies, or by any of the hundreds of non-profit diabetes foundations around the world. “[It] hasn’t even made it into the medical community at this point,” Dr. Carpenter adds. “It takes a long time to change both medical and public opinion.”

“Clearly one thing everyone can do is to eat less animal fats,” suggests Dr. Carpenter. Several Indigenous communities in northern Manitoba and British Columbia have begun to do this, planting their own gardens and building greenhouses; returning, in a traditional sense, to some of the foods that sustained them for millennia. Others are turning to exercise, which plays a vital role not just in the prevention of diabetes, but in their overall health.

“Also, we must find ways of getting the POPs out of the animals that we eat. That is not going to be easy, given how contaminated we have made the world,” adds Dr. Carpenter. For this, Lori Riddle, who is herself a diabetic, points to the Tribal Council and the Federal Government.

Author and Copyright:

John “Ahniwanika” Schertow is an Indigenous rights advocate and author of the blog, Intercontinental Cry. / Contact

Yesterday (Feb 2, 2010), in an independent student newspaper from the University of New Hampshire, a professor of chemical engineering appealed to the community to take “Canaries” into account regarding the use of chemicals and especially scents. He spoke of those persons who suffer from Chemical Sensitivity and who have to be seen – like those former canaries in mines – as indicators for toxic chemicals.

Some American and Canadian Universities have a “Scent Free Policy” which means that the use of perfumes and products containing scents is prohibited within these Universities. All visitors have to meet this policy. It allows students with allergy and chemical sensitivity to work and study.

Professor Ihab Farag, Chemical Engineering Department:

Many of us are familiar with canaries, the beautiful, colorful birds that tend to sing most of the time. Canaries also saved many human lives in coalmines. This is because canaries are much more sensitive to toxic gases than humans. Miners would take canaries with them in the coalmine. If the canary stopped singing and fell (or died), the miners knew to leave the coal mine quickly to safety.

There are individuals who have developed a very strong sensitivity to many common chemicals. These people can be very negatively affected and irritated by fumes, chemical cleaners, disinfectants, cigarette/cigar smoke, engine exhaust, solvents, etc. These people are often called “Human Canaries” of the modern world, because of the chemical sensitivity similarity to that of Canaries. Human Canaries of the 21st century tend to be very strongly irritated by everyday chemicals like perfumes, hair products, shampoos, shower gels, after shave lotions, antiperspirants, deodorants, hand sanitizers, chap sticks, finger nail polish, etc. Human canaries look the same as other people, and when you see one you probably will not recognize he or she is a human canary until an offensive toxic chemical triggers his or her sensitivity.

Please be considerate to human canaries and help them to enjoy life to the fullest. One way you can help the human canary and at the same time lower your exposure to undesirable chemicals, is to go fragrance-free: avoiding perfumes, and fragranced personal care products.

Author: Silvia K. Müller, CSN – Chemical Sensitivity Network, February 2, 2009

Reference:

Chemical consideration to the Human Canaries, Ihab Farag, Professor, Chemical Engineering Department, Letter to the editor 02-02-10, The New Hampshire, Independent Student Newspaper at the University of New Hampshire since 1911, Februar 2, 2010

If it hadn’t been for the Big Macs that Joannie ate pretty much three times a week, she wouldn’t have gotten fat.  If she hadn’t been exposed while in her mother’s womb to chemicals x, y and z, Joannie wouldn’t have had the propensity to get fat.  And if Joannie’s mom had eaten more sensibly, both waistlines would be slimmer.

Fat people most likely are programmed to become fat before taking their first sip of milk.

Today’s news is, that pesticides are among the chemicals responsible for this reprogramming.

Two of three U.S. adults are now classified as overweight.  Type II diabetes has increased in like measure over the same decades, and so has heart disease.  This is not a coincidence.  These illnesses share common characteristics: they are triggered while in the womb by exposure to the same kinds of chemicals and the outcomes show up in adulthood.  Scientists now call this pattern “the fetal origins of adult diseases”.

The most likely culprits are chemicals now grouped together under the rubric “endocrine disrupters.” It’s been known for about two decades, though disputed by the manufacturers, that these chemicals alter the normal signaling pathways of hormones.  Think of Bisphenol A (BPA), right now the nation’s most celebrated endocrine disruptor.

Pesticides, though not specifically thought of as endocrine disruptors nor regulated as such, can similarly knock normal development off track.  Research has just found that a family of pesticides among the most widely used in the world is connected to these three adult illnesses.  This is the family of organophosphates, concocted from petroleum with an addition of phosphoric acid.

When lab rats are exposed to these pesticides through the mother’s diet, at a time in their development equivalent to a human baby’s second trimester in the womb, their metabolism changes in two ways: their cholesterol and triglycerides rise.  These abnormal and lasting changes resemble the major factors that predict and lead, later in life, to obesity, diabetes and cardiovascular heart disease (specifically, atherosclerosis, a condition in which fatty material collects along the arteries and hardens artery walls).

These changes in metabolism happen at low levels, within the levels we are uniformly exposed to, which the Environmental Protection Agency declares as “safe” but are evidently not.  The changes are the strongest when the mother rats are fed a high-fat diet.  Human babies may even be underweight at birth (and there’s an epidemic of underweight babies in the U.S.), but quickly become overweight

Humans run into these pesticides in our food and water.  Of course, children continue to be exposed once they are born and are in fact exposed more than adults because they eat and drink more in relation to their body weight and have a higher ratio of skin.

The other groups of people exposed most to organophosphates and other pesticides are the same groups with the highest rates of obesity – people who live in run-down inner-city neighborhoods, the poor, and farmworkers.  Again, not a coincidence but a connection, a trigger.

Dr. Ted Slotkin of Duke University, the researcher responsible for these discoveries, found another compelling clue: exposure caused harm to the rodent’s brain, as well as its metabolism.  Once the exposed lab animal was born and started to eat at will, its consumption of a high-fat diet reduced the adverse symptoms in its brain functioning.  As Dr. Slotkin muses, “If you’ve got neurofunctional deficits, and they can be offset by continually eating Big Macs, then you will naturally (but unconsciously) select that kind of food because it will make you feel better.”  Unfortunately, increased fat will further harm the animal’s, or human’s, metabolism.

What this means for you:

Particularly while trying to conceive, during pregnancy, while nursing, and for your children, avoid pesticides; eat organic foods.

For information about endocrine disruptors, read the new booklet published by the nonprofit Learning and Developmental Disabilities Initiative.

Author: Alice Shabecoff for CSN – Chemical Sensitivity Network, November 5, 2009

Alice Shabecoff is the co-author with her husband Philip of Poisoned Profits: The Toxic Assault on our Children, published by Random House last year.  See their website, www.poisonedprofits.com

Related article from Alice Shabecoff:

• Our planet, our children – How are your children doing?

Toxic Sofas, toxic Furniture – Searching for a cause  

Sitting in new chairs or sofas has elicited dermatitis in numerous patients in Finland and in the U.K. since autumn 2006. The cause of the dermatitis seemed to be an allergen in the furniture materials.

The aim of the following study was to determine the cause of the dermatitis in patients with furniture-related dermatitis. 

Altogether 42 patients with furniture-related dermatitis were studied. First, 14 Finnish patients were patch tested with the standardized series and with the chair textile material. A thin-layer chromatogram (TLC) strip and an extract made from the same textile material were tested in seven Finnish patients. The test positive spot of the TLC and the content of a sachet found inside a sofa in the U.K. were analysed by using gas chromatography-mass spectrometry. All chemicals analysed were patch tested in 37 patients. 

A positive patch test reaction to the chair textile and to its extract was seen in all patients tested, one-third of whom had concurrent reactions to acrylates. Positive reactions to the same spot of the TLC strip were seen in five of seven patients and dimethyl fumarate was analysed from the spot as well as from the sachet contents. Dimethyl fumarate (0.01%) elicited positive reactions in all the patients. The other chemicals analysed did not elicit positive reactions, but one patient in the U.K. had a positive reaction to tributyl phosphate. 

Sensitization to dimethyl fumarate was seen in all the patients with furniture-related dermatitis. Concurrent sensitization or cross-reactions were common among the sensitized patients. 

Reference:   Lammintausta K, Zimerson E, Hasan T, Susitaival P, Winhoven S, Gruvberger B, Beck M, Williams JD, Bruze M.,  An epidemic of furniture-related dermatitis: searching for a cause., Department of Dermatology, Turku University Hospital, PO Box 52, 20521 Turku, Finland, Br J Dermatol. 2009 Jul 20.

Neurobehavioral and pulmonary impairment in 105 adults with indoor exposure to molds compared to 100 exposed to chemicals 

Patients exposed at home to molds and mycotoxins and those exposed to chemicals (CE) have many similar symptoms of eye, nose, and throat irritation and poor memory, concentration, and other neurobehavioral dysfunctions. Aim of a study was to compare the neurobehavioral and pulmonary impairments associated with indoor exposures to mold and to chemicals. 

105 consecutive adults exposed to molds (ME) indoors at home and 100 patients exposed to other chemicals were compared to 202 community referents without mold or chemical exposure. To assess brain functions, the scientists measured 26 neurobehavioral functions. Medical and exposure histories, mood states score, and symptoms frequencies were obtained. Vital capacity and flows were measured by spirometry. Groups were compared by analysis of variance (ANOVA) after adjusting for age, educational attainment, and sex, by calculating predicted values (observed/predicted x 100 = % predicted). And p < .05 indicated statistical significance for total abnormalities, and test scores that were outside the confidence limits of the mean of the percentage predicted. 

People exposed to mold had a total of 6.1 abnormalities and those exposed to chemicals had 7.1 compared to 1.2 abnormalities in referents. Compared to referents, the exposed groups had balance decreased, longer reaction times, and blink reflex latentcies lengthened. Also, colour discrimination errors were increased and visual field performances and grip strengths were reduced. The cognitive and memory performance measures were abnormal in both exposed groups. Culture Fair scores, digit symbol substitution, immediate and delayed verbal recall, picture completion, and information were reduced. Times for peg-placement and trail making A and B were increased. 

One difference was that chemically exposed patients had excess fingertip number writing errors, but the mold-exposed did not. Mood State scores and symptom frequencies were greater in both exposed groups than in referents. Vital capacities were reduced in both groups. Neurobehavioral and pulmonary impairments associated with exposures to indoor molds and mycotoxins were not different from those with various chemical exposures. 

Reference: Kilburn KH, Neurobehavioral and pulmonary impairment in 105 adults with indoor exposure to molds compared to 100 exposed to chemicals, University of Southern California, Keck School of Medicine (ret.), Pasadena, CA, USA., Toxicol Ind Health. 2009 Sep 30.