Why do smells make some people sick?

Do you get a headache from the perfume of the lady next to you at the table? Do cleaning solutions at work make your nose itch? If you have symptoms prompted by everyday smells, it does not necessarily mean you are allergic but rather that you suffer from chemical intolerance. According to Linus Andersson at Umeå University, this hypersensitivity can be the result of an inability to get used to smells.

Normally your smell perceptions diminish rapidly, as when you enter a friend’s apartment. Even though you clearly notice smells just inside the door, you don’t think about them for long. For people with chemical intolerance, on the other hand, smells seem always to be present. Psychology researcher Linus Andersson has exposed both intolerant and non-intolerant individuals to smells and compared their reactions.

“The hypersensitive individuals felt that the smell was getting stronger even though its concentration had not changed. Their brain activity images also differed from those in the other group,” he says.

The results were observed using methods based on both electroencephalography (EEG) and functional brain imaging technology (fMRI). The EEG method involved placing electrodes on the heads of trial subjects and registering the minute changes in tension in the brain that arise following exposure to smells. Unlike the people in the normal group, Linus Andersson explains, the intolerant people did not evince a lessening of brain activity during the period of more than an hour they were exposed to a smell. The inability to grow accustomed to smells is thus matched by unchanging brain activity over time.

“These individuals also have a different pattern in the blood flow in their brains, compared with those who perceive that a smell diminishes. A similar change can be found in patients with pain disorders, for example.”

Sensitivity to smell impacts the entire body. A further finding in the dissertation is that chemical intolerant people also react strongly to substances that irritate the mucous linings of their nose and mouth. People who cough more when they inhale capsaicin, the hot compound in chili peppers, also have heightened reactions in the brain to other smells. Besides the fact that intolerant individuals perceive that smells grow stronger, effects are also seen in mucous linings and in the brain.

Chemical intolerance is surprisingly common – up to ten percent of the Swedish population report they are bothered by everyday smells, whereas roughly two percent experience severe symptoms. Yet, in contrast to the situation regarding allergies and asthma, there is very little research about what causes this condition. Linus Andersson maintains that if it were possible to identify what characterizes this hypersensitivity then it would be possible to develop methods for diagnosis and treatment. But research can also provide new knowledge about how we should think about our work and everyday environments.

“Some co-workers are bothered more than others by the smell of the printer — what should we do to make our working conditions acceptable to as many people as possible?”

Author:

UMEA University, Why do smells make some people sick?, 20. Januar 2012 Expertanswer (Expertsvar in Swedish

Linus Andersson, Sick of smells: Empirical findings and a theoretical framework for chemical intolerance, Umeå, 2011-12-02

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New Research Shows Two of the Leading Killers in America Might be Linked

“We know there’s a link,” says Heather Snyder, senior associate director of Medical and Scientific Relations for the Alzheimer’s Association. “What we’re trying to find out is the why.”

Snyder is speaking of two of this country’s worst scourges: Alzheimer’s disease and diabetes. Both are major killers. According to the Centers for Disease Control and Prevention, they are, respectively, the sixth and seventh leading causes of death in the U.S.

Now, research has begun to suggest that they share something else besides a capacity for death—namely, a common organic thread. For that reason, research into one may lead to successful means of dealing with the other.

To begin with, 26 million people in the U.S. have diabetes, 7 million of whom don’t even know they are affected, according to the National Institute of Diabetes and Digestive and Kidney Disease. But regardless of awareness, diabetes remains a condition whereby too much sugar builds up in the bloodstream because the body cannot use insulin effectively. That is, the body stops producing sufficient insulin to help cells absorb sugar and turn it into energy.

Certain segments of the population have a disproportionate rate of diabetes, including Hispanic, African, Asian and Native Americans. According to the National Institutes of Health, 8.3 percent of the U.S. population have diabetes, but more than 16.1 percent of the adult population of American Indians and Alaska Natives have been diagnosed with it. The rates of diabetes vary by region, with American Indians in southern Arizona suffering the highest rates in the country at 33.5 percent.

Diabetes and Alzheimer’s have several links. For example, insulin resistance and type 2 diabetes increase the risk of both heart disease and stroke. Damaged blood vessels can result from either of these conditions, and researchers believe that damaged vessels in the brain may well contribute to Alzheimer’s.

Further, our brain cells use a high level of energy, which can be affected by diabetes because the disease retards the body’s ability to absorb sugar to generate the necessary energy. Healthy brain function also depends on a symphony of many different chemicals working in concert. Too much insulin can throw off the balance of these chemicals and potentially trigger Alzheimer’s. Finally, high blood sugar causes inflammation, which could damage brain cells and help Alzheimer’s develop.

Tackling the connection between diabetes and Alzheimer’s disease may ultimately involve a better understanding of vascular dementia, a disease with the same symptoms as Alzheimer’s. But as Snyder puts it, “Of the top 10 causes of death in the United States, Alzheimer’s is the only one without any way to prevent, cure or slow its progression.” Vascular dementia, by contrast, can be prevented or managed through many of the same healthy habits that can also reduce the risk of diabetes.

“[Vascular dementia] results from hypertension, a high-fat diet, smoking and uncontrolled diabetes,” says Carson Henderson, associate director of Two Hawk Institute, an Indian-owned and -operated corporation focused on health education, training and research in Indian country. “If you exercise, eat right, and don’t smoke, you might be able to prevent vascular dementia as you age.”

Vascular dementia is caused by low blood flow to the brain, often as the result of a stroke or series of strokes. “With vascular dementia, your brain cells are dying, because small, tiny blood vessels in the brain are being blocked, and the cells below are not receiving blood or oxygen,” explains Carson Henderson’s husband, Neil Henderson, Oklahoma Choctaw, who directs the American Indian Diabetes Prevention Center at the University of Oklahoma Health Sciences Center’s College of Public Health. “Vascular dementia looks a lot like Alzheimer’s disease, but it is not the same causation. You still get memory loss and confused thinking.”

The latest link between diabetes and dementia was established by a recent study undertaken by Kyushu University in Japan. Researchers analyzed “1,017 community-dwelling dementia-free subjects” over the course of 15 years and found that Alzheimer’s disease and vascular dementia “were significantly higher in subjects with diabetes then in those with normal glucose tolerance.”

Snyder puts the significance of the finding this way: “Diabetes affects your heart, and there are links between cardiovascular health and brain health. The brain uses 25 percent of the oxygen in blood for its functions, if the heart isn’t healthy, the brain won’t be healthy, either.”

So the ties between diabetes and heart disease and stroke continue to be uncovered. Now, with the possibility that diabetes might be among the causes of one of America’s most lethal diseases, organizations like the Alzheimer’s Association are doing everything they can to spread awareness—and prevention.

Source: A Deadly Duo: New Research Shows Two of the Leading Killers in America Might be Linked
By ICTMN Staff December 14, 2011

“We know there’s a link,” says Heather Snyder, senior associate director of Medical and Scientific Relations for the Alzheimer’s Association. “What we’re trying to find out is the why.”

Snyder is speaking of two of this country’s worst scourges: Alzheimer’s disease and diabetes. Both are major killers. According to the Centers for Disease Control and Prevention, they are, respectively, the sixth and seventh leading causes of death in the U.S.

Now, research has begun to suggest that they share something else besides a capacity for death—namely, a common organic thread. For that reason, research into one may lead to successful means of dealing with the other.

To begin with, 26 million people in the U.S. have diabetes, 7 million of whom don’t even know they are affected, according to the National Institute of Diabetes and Digestive and Kidney Disease. But regardless of awareness, diabetes remains a condition whereby too much sugar builds up in the bloodstream because the body cannot use insulin effectively. That is, the body stops producing sufficient insulin to help cells absorb sugar and turn it into energy.

Certain segments of the population have a disproportionate rate of diabetes, including Hispanic, African, Asian and Native Americans. According to the National Institutes of Health, 8.3 percent of the U.S. population have diabetes, but more than 16.1 percent of the adult population of American Indians and Alaska Natives have been diagnosed with it. The rates of diabetes vary by region, with American Indians in southern Arizona suffering the highest rates in the country at 33.5 percent.

Diabetes and Alzheimer’s have several links. For example, insulin resistance and type 2 diabetes increase the risk of both heart disease and stroke. Damaged blood vessels can result from either of these conditions, and researchers believe that damaged vessels in the brain may well contribute to Alzheimer’s.

Further, our brain cells use a high level of energy, which can be affected by diabetes because the disease retards the body’s ability to absorb sugar to generate the necessary energy. Healthy brain function also depends on a symphony of many different chemicals working in concert. Too much insulin can throw off the balance of these chemicals and potentially trigger Alzheimer’s. Finally, high blood sugar causes inflammation, which could damage brain cells and help Alzheimer’s develop.

Tackling the connection between diabetes and Alzheimer’s disease may ultimately involve a better understanding of vascular dementia, a disease with the same symptoms as Alzheimer’s. But as Snyder puts it, “Of the top 10 causes of death in the United States, Alzheimer’s is the only one without any way to prevent, cure or slow its progression.” Vascular dementia, by contrast, can be prevented or managed through many of the same healthy habits that can also reduce the risk of diabetes.

“[Vascular dementia] results from hypertension, a high-fat diet, smoking and uncontrolled diabetes,” says Carson Henderson, associate director of Two Hawk Institute, an Indian-owned and -operated corporation focused on health education, training and research in Indian country. “If you exercise, eat right, and don’t smoke, you might be able to prevent vascular dementia as you age.”

Vascular dementia is caused by low blood flow to the brain, often as the result of a stroke or series of strokes. “With vascular dementia, your brain cells are dying, because small, tiny blood vessels in the brain are being blocked, and the cells below are not receiving blood or oxygen,” explains Carson Henderson’s husband, Neil Henderson, Oklahoma Choctaw, who directs the American Indian Diabetes Prevention Center at the University of Oklahoma Health Sciences Center’s College of Public Health. “Vascular dementia looks a lot like Alzheimer’s disease, but it is not the same causation. You still get memory loss and confused thinking.”

The latest link between diabetes and dementia was established by a recent study undertaken by Kyushu University in Japan. Researchers analyzed “1,017 community-dwelling dementia-free subjects” over the course of 15 years and found that Alzheimer’s disease and vascular dementia “were significantly higher in subjects with diabetes then in those with normal glucose tolerance.”

Snyder puts the significance of the finding this way: “Diabetes affects your heart, and there are links between cardiovascular health and brain health. The brain uses 25 percent of the oxygen in blood for its functions, if the heart isn’t healthy, the brain won’t be healthy, either.”

So the ties between diabetes and heart disease and stroke continue to be uncovered. Now, with the possibility that diabetes might be among the causes of one of America’s most lethal diseases, organizations like the Alzheimer’s Association are doing everything they can to spread awareness—and prevention.

Authors: ICTMN Staff December 14, 2011

Republished by courtesy of Indian Country Today Media Network
Original Source: A Deadly Duo: New Research Shows Two of the Leading Killers in America Might be Linked
Twitter: Indian Country

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UCLA reported about a patient with severe bromine intoxication from drinking orange soda

Patented as a flame retardant for plastics, and banned in food throughout Europe and Japan, a brominated chemical called BVO has been added to sodas for decades in North America. Now some scientists have a renewed interest in this little-known ingredient, found in 10 percent of sodas in the United States. Research on its toxicity dates back to the 1970s, and some experts now urge a reassessment. After a few extreme soda binges – not too far from what many video gamers regularly consume – a few patients have needed medical attention for skin lesions, memory loss and nerve disorders, all symptoms of overexposure to bromine. Other studies suggest that BVO could be building up in human tissues. In mouse studies, big doses caused reproductive and behavioral problems.

By Brett Israel, Environmental Health News, Dec. 12, 2011

MARIETTA, Ga. – It’s Monday night at the Battle & Brew, a gamer hangout in this Atlanta suburb. The crowd is slumping in chairs, ears entombed in headphones, eyes locked on flat-screen monitors and minds lost in tonight’s video game of choice: “The Elder Scrolls V: Skyrim.”

To help stay alert all night, each man has an open can of “gamer fuel” inches from his keyboard. “I’ve seen some of these dudes plow through six sodas in six hours,” said Brian Smawley, a regular at the gamer bar.

Gamers say they chug their fuel for the sugar and caffeine, but drinkers of Mountain Dew and some other citrus-flavored drinks are also getting a dose of a synthetic chemical called brominated vegetable oil, or BVO.

Patented by chemical companies as a flame retardant, and banned in food throughout Europe and Japan, BVO has been added to sodas for decades in North America. Now some scientists have a renewed interest in this little-known ingredient, found in 10 percent of sodas in the United States.

After a few extreme soda binges — not too far from what many gamers regularly consume – a few patients have needed medical attention for skin lesions, memory loss and nerve disorders, all symptoms of overexposure to bromine. Other studies suggest that BVO could be building up in human tissues, just like other brominated compounds such as flame retardants. In mouse studies, big doses caused reproductive and behavioral problems.

Reports from an industry group helped the U.S. Food and Drug Administration establish in 1977 what it considers a safe limit for BVO in sodas. But some scientists say that limit is based on thin, outdated data, so they insist that the chemical deserves a fresh look.

“Aside from these reports, the scientific data is scarce,” said Walter Vetter, a food chemist at Germany’s University of Hohenheim and author of a recent, but unpublished, study on BVO in European soda imports.

Flame retardant soda?

The next time you grab a Mountain Dew, Squirt, Fanta Orange, Sunkist Pineapple, Gatorade Thirst Quencher Orange, Powerade Strawberry Lemonade or Fresca Original Citrus, take a look at the drink’s ingredients. In Mountain Dew, brominated vegetable oil is listed next-to-last, between disodium EDTA and Yellow 5. These are just a sampling of drinks with BVO listed in their ingredients, which is required by the FDA. The most popular sodas – Coca-Cola and Pepsi – do not contain BVO.

You don’t have to be a gamer to drink these fruit-flavored sodas. In the United States, 85 percent of kids drink a beverage containing sugar or artificial sweetener at least once per week, according to a study published last month. Sodas are the largest source of calories for teenagers between the ages of 14 to 18, according to a National Cancer Institute study. For adults, soda, energy and sports drinks are the fourth largest (PDF) source of calories, a federal study found.

Hold a bottle of Mountain Dew to a light. It’s cloudy. Brominated vegetable oil creates the cloudy look by keeping the fruity flavor mixed into the drink. Without an emulsifier such as BVO, the flavoring would float to the surface. The FDA limits the use of BVO to 15 parts per million in fruit-flavored beverages.

Brominated vegetable oil, which is derived from soybean or corn, contains bromine atoms, which weigh down the citrus flavoring (PDF) so it mixes with sugar water, or in the case of flame retardants, slows down chemical reactions that cause a fire.

Brominated flame retardants lately are under intense scrutiny because research has shown that they are building up in people’s bodies, including breast milk, around the world. Designed to slow the spread of flames, they are added to polystyrene foam cushions used in upholstered furniture and children’s products, as well as plastics used in electronics. Research in animals as well as some human studies have found links to impaired neurological development, reduced fertility, early onset of puberty and altered thyroid hormones.

BVO may not be in use today as a flame retardant in furniture foam, but patents in Europe — granted earlier this year to Dow Global Technologies — and in the United States — granted in 1967 to Koppers Inc. — keep that possibility alive.

“There are some concerns [about BVO] because people are worried that maybe it has the behavior, [and] potential health effects similar to brominated flame retardants,” said Heather Stapleton, an environmental chemist at Duke University who specializes in studying brominated compounds.

Soda makers and industry groups say they are not concerned about the safety of brominated vegetable oil, saying their products meet all government standards.

“This is a safe ingredient approved by the FDA, which is used in some citrus-based beverages,” said Christopher Gindlesperger of the American Beverage Association, which represents PepsiCo, maker of Mountain Dew. “Importantly, consumers can rest assured that our products are safe and our industry adheres to all government regulations.”

Chris Barnes of the Dr. Pepper Snapple Group, makers of Squirt and other drinks that contain BVO, echoed that response.

“All ingredients in Dr. Pepper Snapple Group products meet FDA and other regulator requirements,” Barnes said.

Dated data

Some experts are unconvinced, saying that the FDA standards are based on decades-old data.

“Compounds like these that are in widespread use probably should be reexamined periodically with newer technologies to ensure that there aren’t effects that would have been missed by prior methods,” said Charles Vorhees, a toxicologist at Cincinnati Children’s Hospital Medical Center, who studied BVO’s neurological effects in the early 1980s. “I think BVO is the kind of compound that probably warrants some reexamination.”

Toxicity testing has changed dramatically in the past few decades. Multiple generations of animals now can be tested for neurodevelopmental, hormonal and reproductive changes that weren’t imagined in the 1970s and early 1980s.

“I am no toxicologist, but I think that the toxic evaluation of chemicals has been improved since then,” Vetter added.food chemist.

In 1970, scientists in England found that rats on a six-week diet containing 0.8 percent brominated maize oil had stockpiles of bromine in their fat tissue. The bromine stayed there even after the rats returned to a control diet for two weeks.

Around the same time, a study confirmed that bromine was building up in humans. Researchers measured the serum levels of people in the United Kingdom – where BVO was in use – and in their counterparts in the Netherlands and Germany, where BVO was not used.

“During this time UK citizens had higher bromine serum levels compared to the inhabitants of Germany and the Netherlands,” Vetter said. The largest amounts of lipid-bound bromine were found in tissues from children in the UK, according to the study.

The study authors wrote that “it seems highly probable that the intake of brominated vegetable oil is the cause of the tissue bromine residues in children.”

Data in rats show that BVO could be toxic. A 1971 study by Canadian researchers found that rats fed a diet containing 0.5 percent brominated oils grew heavy hearts and developed lesions in their heart muscle. In a later study, in 1983, rats fed the same oils had behavioral problems, and those fed 1 percent BVO had trouble conceiving. At 2 percent, they were unable to reproduce.

The diets in that study had “whopping doses” of BVO, about 100-times higher than today’s allowable limit, said Vorhees, lead author of the 1983 study.

But two case studies in the past 15 years show that whopping doses also can occur in people – with unhealthy consequences.

Epic binges

On MMO nights at the Battle & Brew, some gamers play 12 straight hours. In these Massively Multiplayer Online games, thousands of players from around the world compete. During these epic battles, a soda every hour is not uncommon. A gamer chugging a 20-ounce bottle of soda every hour will finish 3.5 liters in six hours.

“They’re just sitting for 12 hours, just pounding sodas,” Smawley said.

Virtually every teen in America plays video games, according to the Pew Research Center. The $110-billion-a-year soft drink industry and the $74-billion-a-year video game industry have noticed. Activision, the makers of “Call of Duty: Modern Warfare 3,” the latest edition in this popular video game series, paired with Mountain Dew in a promotion that rewards gamers with bonus points for drinking more Mountain Dew.

In 1997, emergency room doctors at University of California, Davis reported a patient with severe bromine intoxication from drinking two to four liters of orange soda every day. He developed headaches, fatigue, ataxia (loss of muscle coordination) and memory loss.

In a 2003 case reported in Ohio, a 63-year-old man developed ulcers on his swollen hands after drinking eight liters of Red Rudy Squirt every day for several months. The man was diagnosed with bromoderma, a rare skin hypersensitivity to bromine exposure. The patient quit drinking the brominated soft drink and months later recovered.

Reactions this severe may not be a concern in the general population, the study’s doctors said.

“Any normal level of consumption of BVO would not cause any health problems — except the risk of diabetes and obesity from drinking that much sugar water,” said Zane Horowitz, medical director of the Oregon Poison Center and author of the 1997 case study.

But in the gamer scene, a normal level of consumption is not normal. Everyone, it seems, knows someone habitually needing a fuel fix, and consuming enough to up his or her risk.

“I’ve seen hard core guys, after every game they’ll just grab another one,” said Sean Hyatt, the assistant manager at the Battle & Brew.

And it’s not just the “stinkies” – Smawley’s derogatory term for the stereotypical gamer slobs – who pound gamer fuel. Vorhees, of the Cincinnati children’s hospital, said his son stays up all night when playing a new game with his friends.

“They use Mountain Dew specifically as a beverage to keep them awake – and they hardly eat anything,” Vorhees said.

When a person doesn’t eat during one of these binges, his or her body is absorbing the entire beverage. It’s even worse in kids, Vorhees said, because they have less body mass.

“In kids, the total dosage effect tends to be greater,” Vorhees said. “I actually think there are people that get these high exposures.”

Banned bromine returns

Based on data from the early studies, the FDA yanked brominated vegetable oil from its Generally Recognized as Safe (GRAS) list for flavor additives in 1970, said Douglas Karas, a spokesman for the FDA. BVO bounced back after studies from an industry group from 1971 to 1974 demonstrated a level of safety.

The Flavor Extract Manufacturers’ Association petitioned the FDA to get BVO back in fruit-flavored beverages, this time as a stabilizer, which is its role today. After evaluating the petition and other data, the FDA in 1977 approved the interim use of BVO at 15 ppm in fruit-flavored beverages, pending the outcome of additional studies.

“This decision was based on the highest No Observed Effect Levels from the existing safety studies and the estimated daily intake,” Karas said in an email. “Although there were doses that showed adverse effects in the animal studies, there also were lower doses in which there were no adverse effects observed.”

As a condition of interim approval, the industry group submitted additional safety studies to the FDA.

The FDA determined that a 2-year feeding study in pigs established a no-effect level of 1,200 ppm. A 2-year feeding study in beagle dogs also was conducted. Although there were concerns about quality control with that particular study, Karas said, no cardiovascular effects were observed in the dogs fed BVO at levels as high as 3,600 ppm for two years. After an independent audit of the data to address the quality concerns, the FDA decided to allow BVO in fruit-flavored beverages.

“The findings from these studies supported the safety of BVO in beverages at a level of 15 ppm in fruit-flavored beverages,” Karas said. “Its use as a flame retardant does not preclude its use as a food ingredient so long as the food use is safe.”

More than 30 years later, brominated vegetable oil’s approval status is still listed as interim. Changing the status would be costly and “is not a public health priority for the agency at this time,” Karas said.

Michael Jacobson, executive director of the Center for Science in the Public Interest, was involved with the petition to remove BVO from the “safe” list in 1970. He said it’s time for the FDA to make a decision, one way or the other.

“Is it harmful at the amounts consumed? Probably not,” Jacobson said. “But it would be nice if the FDA did a thorough review of the literature and finalized an approval or a ban.”

A safer switch?

BVO has seeped into Europe, mostly forbidden territory for this additive, according to an analysis (PDF) of imported sodas presented at an international symposium on halogenated persistent organic pollutants in 2010.

“We found products with no label although BVO was present in the soda,” said Vetter, lead author of the study.

He said soda makers in North America could easily replace BVO with alternatives such as hydrocolloids – chemicals that are used in many sodas in Europe. Natural hydrocolloids form small droplets on water into which non-water soluble compounds can be stored and stabilized for as long as necessary. They are almost exclusively natural products, Vetter said.

Barnes, of the Dr. Pepper Snapple Group, said that BVO and hydrocolloids “do not provide the same functionality and cannot be substituted for one another.”

Vetter disagreed, saying that countries in Europe and elsewhere have used natural hydrocolloids for decades in the soda brands that rely on BVO in North America.

“There are many options to substitute BVO with safe chemicals,” Vetter said. “I am not aware of significant disadvantages of BVO over hydrocolloids or vice versa.”

With natural alternatives already in use in other countries, why not switch in North America too?

Wim Thielemans, a chemical engineer at the University of Nottingham in the United Kingdom, said since the alternatives are already used in Europe “their performance must be acceptable, if not comparable, to the U.S.-used brominated systems.” That means “the main driver for not replacing them may be cost,” he said.

“It is a North American problem,” Vetter added. “In the E.U., BVO will never be permitted.”

Source: EHN, Brominated Battle in Sodas, Dec. 12, 2011

CC: by-nc-nd

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Multiple Chemical Sensitivity: Reflections by Dr. L. Christine Oliver and Alison Johnson

Dr. Oliver and Alison Johnson present an excellent overview of the multi-symptom disease known as Multiple Chemical Sensitivity, or MCS. During Dr. Oliver’s twenty years of experience, she can attest to MCS being a physiological disease with clear visual manifestations, such as flushing of skin, increased heart rate, and blood pressure problems in patients exposed to chemicals.

As MCS is ever increasing, Dr. Oliver (Associate Professor of Clinical Medicine, Harvard Medical School; Co-Director of Occupational and Environmental Medicine, Massacsetts General Hospital) advocates for more research dollars dedicated to finding modalities to treat MCS. Medical students and physicians are still not trained about MCS even though it affects the respiratory, neurological, gastrointestinal systems, and even the skin. Pulmonologists, gastroenterologists, and allergists, just to name a few, are the physicians who must receive appropriate training.

Currently, most physicians cannot give a correct diagnosis which leaves patients feeling more isolated and thus many chemically injured seek alternative treatments, some which may do more harm than good. According to Dr. Oliver there are no miracle cures for MCS and currently the most reliable treatment is avoidance of exposures.

The disabling symptoms do much to interfere with a MCS person’s life. It interferes with using public transportation, living in multi-housing units, and gaining/keeping employment. Dr. Oliver advocates for every workplace to maintain perfume free environments. Public health policies are needed to accommodate people with MCS so they are not forced to turn to social security disability for a reduced income.

Housing is a big issue for the chemically injured. Multi-family housing is a problem due to the neighbors using scented chemical products. Many people with MCS can no longer work and thus don’t have the finances to rent or buy single family housing.

The lack of safe housing, lack of safe workplaces, and medical issues can be overwhelming for those with chemical injury. The despair associated with lack of the above, plus the disbelief that the illness is real, leads many to contemplate and actually commit suicide.

Alison Johnson has witnessed the real devastation of this disease which has destroyed far too many lives. So many MCS people have seen their former lives slip away. This is hardly a “rare” condition with an estimated seven million Americans suffering from MCS. More accurate educating of the public is needed.

The tobacco industry succeeded for years in their funding attempts to keep the public in the dark regarding the negative health risks of tobacco. The chemical industry is also doing a good job preventing the public from realizing the harm from the chemically laden products on the market. In the meantime people on every continent are suffering great devastation, isolation, and compromised lives due to the chemical injuries they have suffered and must endure.

Have a look at this excellent film overview…

For further information vistit: The Chemical Sensitivity Foundation

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The results of a study published this week by environmental health researchers evaluates the types of toxic exposure faced by Veterans with Gulf War illness, and it will hopefully encourage other medical experts to do similar research, West Virginia Veterans’ benefits attorney Jan Dils said today.

The article appears in the journal Environmental Health Perspectives and reports that troops were exposed to different toxins depending on if they served in the front lines or in support roles during the 1991 Gulf War.

Forward-deployed troops were exposed to anti-nerve agent pills and Scud missiles, whereas those behind the scenes were commonly in contact with pesticides, according to the study.

Around 25 percent of the 700,000 Veterans with Gulf War illness are plagued by symptoms including chronic headaches, widespread pain, memory and concentration problems, persistent fatigue, gastrointestinal problems, skin abnormalities and mood disturbances, Dils said.

“Gulf War illness can be a truly disabling disease,” said Dils, whose law firm helps Veterans with disability claims in West Virginia and across the country. “Veterans manage these symptoms as best as they can, but more research into the nature of the disease and its causes could create better treatment opportunities for sufferers.

“It could also provide insight into the most dangerous toxins used in chemical warfare so that other avenues could be explored to protect soldiers who continue to serve in the Gulf War,” the Parkersburg attorney added.

Over 110,000 Gulf War Veterans – which the U.S. Department of Veterans Affairs classifies as those who participated in Operations Desert Storm, Desert Shield, and a subsequent stabilization period during the early 1990s – are currently receiving VA health care, according to a February report from the VA. That includes treatment for the symptoms of Gulf War illness and other related conditions.

“Unfortunately, those numbers continue to grow, and the VA program is overloaded with Veterans’ claims,” said Dils. “That can make it very difficult for Veterans to receive disability benefits they deserve, so they don’t get the treatment and services they are entitled to.”

But the administrative backlog is only one of the problems Veterans face. It’s not easy to apply for disability benefits in the first place, and many times Veterans must go through a lengthy appeals process, Dils said.

“That’s not to mention that these men and women, who have chosen to serve the country at great personal peril, are often very sick,” she said. “Many times their families cannot take up the cause on their own. That’s where a Veterans’ benefits attorney and claims representatives can step up and help, particularly because egregious cases may end up in the Court of Appeals for the Federal Circuit or the U.S. Supreme Court.”

Environmental health results like the ones published this week have the potential to provide vital information about how toxins affect soldiers’ bodies. Previous research has focused on exposure to anthrax shots, depleted uranium and psychological issues, but less so on exposure to anti-nerve-agent pills and insecticides.

“The important thing is to build a body of knowledge that examines the medical consequences of military service,” Dils said. “That can educate all of the interested parties – the disabled Veterans and their families, doctors, scientists, the federal government and even lawyers – to provide services that will benefit the country and honor Veterans for their contributions.”

Author: Jan Dils, Attorneys at Law, L.C., Parkersburg, WV (PRWEB), September 26, 2011

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Several experts from different European countries agree that Electromagnetic Hypersensitivity is a real, physical illness and for some of them this condition seems to be strictly related to Multiple Chemical Sensitivity (MCS). This is what came out of the congress “Mobile Telephony, Wi-Fi, Wi-Max: Are there Health Risks?”, held at Palazzo Marini – Chamber of Deputees in Rome on 14 June 2011. The event, organized by the Association for Environmental and Chronic Toxic Injury (A.M.I.C.A.), was meant to give an overview on the health dangers linked to the use of wireless devices.

Prof. Dominique Belpomme, Oncologist, Professor of the Centre Hospitalier Universitaire Necker-Enfants Malades, Chairman of Research for Anti-Cancer Therapeutics (ARTAC), in his lecture “Diagnostic and Therapeutic Protocols for Electromagnetic Fields Intolerance”, showed the results of a clinical observation on more than 450 patients enrolled from 2008 to 2011. He and his team use a new technique to make the diagnosis to people reporting reactions to electromagnetic fields, a condition that he prefers to define as “Electromagnetic Fields Intolerance” or “EFI Syndrome” rather than “Electromagnetic Hyper-Sensitivity”.

The new technique is the “Pulsed Eco-Doppler” of the brain that combines the eco-doppler with a computer to evaluate brain perfusion. Unlike some other methods, this one is not dangerous and it does not involve any ionizing radiation. The results show that people with Electromagnetic Fields Intolerance have a reduced perfusion in the brain, particularly in the left part of the limbic area of the brain, compared to the control group. This is a very particular area, because it is the “ancient” part of the brain that controls many body functions.

“These results are very important – Belpomme said at the congress – because for the first time we are able to define the Electromagnetic Fields Intolerance as a physical illness based on objective tests”.

His team uses also other tests, such as the dosage of histamine, of protein S100B, and of heat shock proteins hsp70 and hsp27 in the blood. The 70% of the group of patients observed showed a serious reduction of vitamin D, about 1-2% of the patients showed an increase of proteins hsp27 and hsp70, while more than the 40% of the sample had increased histamine, a fact that is fully compatible with a physiological interpretation of this syndrome.

About 10% of the patients had an increased protein S100B, which is a marker for Blood Brain Barrier (BBB) permeability. In one third of the sample, a reduction of melatonin in urine was found, and this can explain symptoms such as fatigue, insomnia and depression in these patients.

These alterations are quite similar to the ones found in patients with Multiple Chemical Sensitivity (MCS), particularly regarding the brain perfusion reduction, the neurogenic inflammation, the oxidative stress increase, and the reduction of the defense mechanism. The fact that EMF induces the opening of the BBB may interfere with the brain protection from toxic chemicals. It is not uncommon, in fact, that patients with EFI Syndrome have MCS symptoms, while many patients with MCS also react to EMF.

The increase of oxidative stress in electrosensitive patients was found also by Dr. Valeria Pacifico, who lectured in Rome about “Metabolic biomarkers of oxidation-reduction imbalance and susceptibility to non-ionizing radiation”. She works in the team of Dr. Chiara De Luca at the Experimental Laboratory BILARA at Istituto Dermopatico of Immaculata in Rome that published several works on the role of oxidative stress in environmental sensitivities. (1, 2)

“To make a diagnosis of this syndrome we need to listen first to patients and we need to verify if the symptoms improve or disappear when they stay away from EMF sources”, Prof. Belpomme explained. In order to demonstrate if the electromagnetic fields were the real cause of the alterations found in these patients, the patients had to repeat the tests before and after a period of avoidance of EMF for three months. The results show that after the period of avoidance the levels tend toward the normal standard.

Given the strong correlation found by six epidemiologic studies on EMF exposure and Alzheimer Disease (AD), Prof. Belpomme believes that any electrosensitive patient with memory dysfunctions should be evaluated also for AD. He stresses the fact that AD is a loss of long term memory while EFI Syndrome often involves the loss of short term memory, but this symptom may be considered as a pre-Alzheimer condition.

Prof. Olle Johansson, Assoc. Prof., The Experimental Dermatology Unit, Department of Neuroscience, Karolinska Institute; Professor, The Royal Institute of Technology, Stockholm, talked in Rome about “The precautionary principle: from Bioinititive to the Seletun consensus”. He dedicated his lecture to people affected by EHS and MCS because “they have a very difficult life”.

He is one of the most dedicated scientists in the promotion of new biologically-based safety guidelines for EMF. He was in Benevento for the ICEMS resolution in 2006, then in London in 2007 for a new resolution, and he was also member of the group of independent scientists that published the famous Bioinitiative Report in 2007, which had strong ecological concern in the political agenda. Thanks to this report, in fact, the European Parliament signed a resolution on September 4, 2008 to state that the actual safety limits for EMF are obsolete and to warn EU governments about the increase of new environmental illnesses such as EHS, MCS and Dental Amalgam Mercury Syndrome.

More recently, Prof. Johansson was part of the group of scientists who prepared the Seletun Consensus, published last February in Reviews on Environmental Health (3). It states that present standards do not protect global human population from electromagnetic fields and all EMF should be reduced now instead of waiting for a definitive proof of danger. It also states that people reporting EHS symptoms should be considered as having a functional disability.

In Sweden, for example, EHS, MCS and fibromyalgia are already classified as functional disabilities. This means that people affected by these conditions are not considered patients, but it’s the environment that creates limitations for them so it’s the environment that has to be changed. This kind of classification represents the full concretization of the UN Convention on the Rights of Persons with Disabilities, signed by governments on March 30, 2007. This convention should be enough to push all governments to find the right accommodation and the best welfare strategies for people with environmental sensitivities, and put an end to discrimination.

Author: Francesca Romana Orlando, journalist and Vice President of A.M.I.C.A.

Literature:

1. De Luca C. et al., Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes, Toxicology and Applied Pharmacology, YTAAP-11818; No. of pages: 8; 4C.
2. De Luca C. et al., The Search for Reliable Biomarkers of Disease in Multiple Chemical Sensitivity and Other Environmental Intolerances, Int. J. Environ. Res. Public Health 2011, 8, 2770-2797; doi:10.3390/ijerph8072770
3. Fragopoulou A ed al., Scientific panel on electromagnetic field health risks: consensus points, recommendations, and rationales, Rev Environ Health. 2010 Oct-Dec; 25(4):307-17.

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Whilst facing a worldwide fast increase of food and environmental allergies, the medical community is also confronted with another inhomogeneous group of environment-associated disabling conditions, including multiple chemical sensitivity (MCS), fibromyalgia, chronic fatigue syndrome, electric hypersensitivity, amalgam disease and others. These share the features of poly-symptomatic multi-organ cutaneous and systemic manifestations, with postulated inherited/acquired impaired metabolism of chemical/physical/nutritional xenobiotics, triggering adverse reactions at exposure levels far below toxicologically-relevant values, often in the absence of clear-cut allergologic and/or immunologic involvement.

Due to the lack of proven pathogenic mechanisms generating measurable disease biomarkers, these environmental hypersensitivities are generally ignored by sanitary and social systems, as psychogenic or “medically unexplained symptoms”. The uncontrolled application of diagnostic and treatment protocols not corresponding to acceptable levels of validation, safety, and clinical efficacy, to a steadily increasing number of patients demanding assistance, occurs in many countries in the absence of evidence-based guidelines.

De Luca et. al. revised available information supporting the organic nature of these clinical conditions. Following intense research on gene polymorphisms of phase I/II detoxification enzyme genes, so far statistically inconclusive, epigenetic and metabolic factors are under investigation, in particular free radical/antioxidant homeostasis disturbances. The finding of relevant alterations of catalase, glutathione-transferase and peroxidase detoxifying activities significantly correlating with clinical manifestations of MCS, has recently registered some progress towards the identification of reliable biomarkers of disease onset, progression, and treatment outcomes.

Literature:

De Luca C, Raskovic D, Pacifico V, Thai JC, Korkina L., The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances, Tissue Engineering & Skin Pathophysiology Laboratory and 2nd Dermatology Division, Dermatological Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167, Italy; Int J Environ Res Public Health. 2011 Jul;8(7):2770-97. Epub 2011 Jul 1.

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• Research on Multiple Chemical Sensitivity (MCS)
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Let me live!

Patrick is 19. His American football gear is in his closet, and in the corner of his room his electric guitar lays on the shelf next to the brilliant lyrics he wrote. His songs have a meaning, not just modified, banal versions of some well-worn songs that were eventually on the top of the charts. No way. Patrick’s music gets down to business and strongly suggests that the songwriter is not a wimp, but instead confident and that he has something significant to say. When Patrick wrote the songs/music, he went to high school, which earlier posed no problem for him, and he enjoyed a life outside of school as well. His buddies were always with him. Life then was to be lived! But now the American football equipment, the guitar, the unfinished recordings, and song books remain on the dusty shelves.

Those were the times

When Patrick lies on his bed in his room it seems like decades since he was with his band buddies on the stage. Sometimes he has flashbacks where he again sees the faces of the girls in front row of the stage, glowing, looking reverently up and so moved by the band’s damn good music. When these flashbacks return, Patrick is reminiscent of the life he used to live. Patrick would like to scream really loud so everyone can hear:

“My body and my pain hold me prisoner. I cannot leave and live like others. A broken body makes me a cripple. It forces me to not always do things that I would like to do. But I want to live.”

Causes and effects

Patrick is sick from chemicals and his body has developed an extreme form of chemical sensitivity (MCS). Some chemicals have the capacity to sensitize the body. In medicine, this is well known that some chemicals like formaldehyde, isocyanates, and some pesticides are able to cause illness. Everything has played a role in Patrick’s current condition. His father was a chemist and had 30 years of contact with chemicals which are capable of damaging genes. No one can define precisely the effects of the countless years of exposures from the not so harmless chemical cocktails where Patrick’s father worked. The fact is, that Patrick’s father, because of work-related health issues, no longer has his health and is seriously ill. Perhaps the house where the family lived also played a role in the illness. Seven times they had high water which left mold on the walls. The walls were washed extensively with chlorine, a highly toxic chemical. Also the wood preservatives in the house could have played a part in Patrick’s state of health.

Others have lived at least

The average age of people who are chemically sensitive, is from 35-45 years, according to studies. There are also sufferers who are much older and some who are still toddlers, but the majority of sufferers had a life before MCS. For Patrick, it’s different:

“Excuse me, I don’t want to offend the others, but the other MCS sufferers were allowed to enjoy prior life experiences (youth, school, training, travel, friends, partnership, etc.), but I was denied everything from the beginning. The best time of life, my youth, has not been granted to me. On the contrary, I am going through hell, but no one is interested, because they do not believe me.”

Ciao buddy

After Patrick broke down completely, the compassion of his buddies and classmates was just great. They came to visit him and provided him with information from school. That gave him the opportunity to continue his school for awhile. When that was no longer possible, he tried getting his education on the internet, via a correspondence school. But now that is over. No more calls, no more visits. Patrick experiences unbearable pain as he feels like he too is covered in dust like his guitar. The girlfriend he had whom he wanted to build a life with, now also lives a life without him, perhaps with someone else. Patrick experiences pain on another level besides just the excruciating physical pain of the illness. He is furious and says:

“I cannot believe that since I’m not out there, I must not be forgotten and do not exist. My struggle must not be in vain.”

“It is hard to accept that everything I have achieved to this point is destroyed.”

“I have resigned myself that I will probably always remain living alone. There is no compassion for this disease. In fact, on the contrary, I am immediately excluded. What girl or young woman is prepared to make such a sacrifice, and how will I even find a person when I need to live a life of isolation? Forget it. This also applies to other friendships as well. ”

“Although various people helped me earlier, now only two friends remain – I’ve always given everything and now … I’m just dropped, since I cannot keep up and have become too annoying or too complicated to all the others.”

To go out at least once

Besides all the bad luck Patrick and his parents experienced in the past, they also lost their most faithful companion too. So Patrick’s mother bought a new dog so that her son has some life in the house and finds some comfort through the love of an animal. The decision was good for the dog and he is very fond of Patrick:

“As much as I would love to be in nature for a couple of hours with our dog for training or just playing only with him, I am not even granted this.”

Simply cut the strings and let the frustration out

If Patrick was frustrated, it was hard to miss. He grabbed his guitar and the sparks were flying as he sang until the walls shook. That has not happened often, but when it did, everyone in the house knew after two minutes. Music is life and a way to express yourself, to let out what the mind has suppressed. But even allowing the frustration and the anger to be let out, is no longer possible for Patrick:

“Playing guitar and singing means so much to me, but my damn body does not even allow that. The muscle weakness and pain again slow me down, and of course, my dream of American football is over.”

MCS means in the worst stage of a “life” in total isolation

Patrick is one of the MCS patients who having a life outside the four walls is impossible. It should not be confused that these people do not want to be, among others, but on the contrary, the wish and desire to do something with other people remains every day around the clock. It is not a psychological problem or fear of people. The body simply gives up when exposed to chemicals. Car exhaust, heater exhaust gases, perfumed people, houses, from which wafts the cleaning products. All chemical cocktails present a difficulty for chemically sensitive people to have a chance to move about.

A short contact with the outside world means having extreme pain, seizures, difficulty breathing, collapse, or unconsciousness. The same applies for visiting. If someone comes to visit, the joy for Patrick can quickly lead to disaster. The deodorants or residues from the dry cleaners in the jacket, fabric softeners, which cannot be totally washed out will make the visit impossible. Utter nonsense? Not at all. Who will make the effort to find appropriate ingredients for “everyday products” that will bring about severe consequences for a man whose body is hypersensitive? What companies will makes the effort to accommodate hypersensitive individuals as they produce products? Not even most doctors will attempt to understand this chemical hypersensitivity. This is due partly out of ignorance, because they have never heard of the disease, and simply because they lack time to investigate further. And if doctors are not smart and declare the disease as a quirk of convenience, how can ordinary people understand those with MCS?

Patrick’s opinion on MCS:

“MCS is the worst disease out there; sometimes I wish I was a paraplegic. I know this sounds harsh, but I would not be so isolated, left alone, not credible, and would have no pain. I could travel in spite of this handicap, going almost everywhere, going to concerts, meeting friends, and possibly make training, and, and. “

The whole family is ruined

Patrick’s parents are willing to do anything for their son, so he can have his life back. But MCS is too complex to just fight the disease with medicine and a few natural remedies. One must start by establishing a clean living environment. Patrick and his father would need a living space that is chemical-and mold-free as much as possible. But how do you implement that? The house in which they have is hard to change due to the financial loss due to his father’s illness.

Help from authorities? No

Patrick should actually have a good case for the authorities to help, but because he has no education, there is no funding, no basic security, which is humiliating for the young man. His mother says:

“We get help from nowhere, in fact, it is quite the opposite. We are harassed by authorities and they make demands on Patrick which he cannot satisfy. Anyone who can count to three must see that. But nobody takes the trouble to look at the misery, instead, decisions are made that are devoid of any humanity. Yes, Patrick virtually exists only on the card. This illness ruined my two men and those who might know how to help and change things for us, look away too easily! ”

“Many people ask me, how has this total isolation been for over the last two years? They say to me, “I would go mad …. I would go crazy … I imagine the bad, and, and …” They also ask, “Where does Patrick, or where do you get the strength to keep going?”

The response from Patrick’s mother: “You can see that Patrick lives and we also manage. Somehow we are probably fighting spirits and do what we try to be bold, brave, and strong willed to survive. The struggle for justice makes us stronger. “That’s what Patrick’s mother says to the outside world, but inside she often thinks, how long does will the body last, like the heart muscle. Every day she must be available around the clock for her men. Every day is actually a struggle for survival, for Patrick, as well as his father.

Optional: a human decision

That which was given to Patrick and his parents since March 2009, is staggering. His parents submitted an application to determine his level of disability. Now a court ruling says that the 19-year-old man who is suffering from unbearable pain all day, and reactions to chemicals must go into a hospital. The hospital has assured the court that it is equipped for emergencies so there shouldn’t be any problems.

• What if he’s there and collapses completely? Who bears the responsibility for him then?
• Who pays to stay in a hospital environment abroad, because in Germany there is no help?
• Can a normal emergency procedure help him to bounce back?
• What if not?

There are no environmentally controlled hospitals for MCS patients in Germany. No hospitals can assure a complete freedom from chemical exposures at all. The hospital rooms discussed in a previous CSN article which are in Hamburg for the environmentally ill, are still not in full operation and they are also only for medical intervention, not for environmental treatment. Thus Patrick’s health would possibly be further compromised by this current court ruling the way it now stands.

So far, instead of support costs caused

Administrative expenses have already cost a fortune for Patrick, a 19 year old, with unbroken will to live. Legally, there is the possibility of seriously ill people remaining in their homes, and being examined within the safety of their own four walls. For Patrick, allowing this would be an act of humanity. This young man wants nothing more than for his disability to be determined. His disability and disease are detected nowhere better than in his own home where everyone can see with their own eyes what the illness actually means for Patrick and his family.

Authors: Silvia Müller and K. Kira, CSN – Chemical Sensitivity Network, 9 July 2011

Translation: Christi Howarth

Note: Patrick’s documents are complete before CSN.

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The Markingson Files: Why health writers should track the money behind medical studies

One of the biggest oversights a health writer can make is to cover a scientific study and not talk about its funders.

Funding with strings attached can affect a study’s outcomes. In 2003, a study in the British Medical Journal found that “Studies sponsored by pharmaceutical companies were more likely to have outcomes favouring the sponsor than were studies with other sponsors.”

This can be as a result of researchers working hard to please their funders and keep the money spigot open. It also can be because of pressure from the drug companies – even subtle pressure – to generate positive results.

In October 2009, AstraZeneca agreed to pay $520 million to settle federal investigations and whistle-blower lawsuits over the company’s marketing practices for the antipsychotic drug Seroquel, including allegations that the company had manipulated research data for marketing purposes. As the New York Times wrote at the time, “Seroquel was the top-selling antipsychotic drug in America. It had $17 billion in sales in the United States since 2004, according to IMS Health, a research firm.”

An after-market clinical trial for Seroquel, called the CAFE study, was conducted at the University of Minnesota to prove that Seroquel was better than its competitors, and one of the trial participants, Dan Markingson, killed himself during the trial.

Carl Elliott, a bioethicist at the University of Minnesota, documented some of this alleged manipulation by using records he found in lawsuits against the company.

The pressure to make Seroquel look superior began as early as 20 years ago, when the drug was still in its early stages.

In the late 1990s, a multi-center clinical trial, known as Study 15, failed to show that Seroquel was better than Haldol, or haloperidol, an older antipsychotic that has been on the market since the 1960s. By some measures, Seroquel performed worse than Haldol. Making matters worse, the study showed that Seroquel boosted the risk of weight gain and diabetes. Internal correspondence repeatedly referred to Study 15 as a “failed study,” and company officials discussed ways to spin it or bury it.

In the Seroquel Strategic Plan 1997-2001, the company wrote on Page 17, “With the failure of Study 15, the Strategy Team reevaluated the Phase IIIB program and determined that the level of risk had to be reduced, as failure of another large scale trial, eg treatment resistance, would result in significant damage to the brand’s market perception if there weren’t other trials successfully completed in parallel.”

Referring to Study 15, Richard Lawrence, a senior Astra Zeneca official, wrote in February 1997 memo, “I am not 100% comfortable with this data being made publicly available at this time…however I understand that we have little choice….Lisa has done a great ‘smoke-and-mirrors’ job!”

Lisa Arvanitis, another AstraZeneca official, was CC’d on the memo, as was AstraZeneca’s Don Stribling. Lawrence also wrote, “Adopting the approach Don has outlined should minimize (and dare I venture to suggest) could put a positive spin (in terms of safety) on this cursed study.”

In November 1997, an AstraZeneca physician wrote an email to a researcher explaining why the company could not fund his study. “R and D is no longer responsible for Seroquel research,” he wrote. “That’s the responsibility of sales and marketing.” He also noted that funding would be more likely if the study could show a “competitive advantage for Seroquel.”

In a May 1999 email, John Tumas, an AstraZeneca publications manager, wrote that he was worried that the company was “cherry-picking data.”

“We’ve buried trials 15, 31 and 56, and now we’re considering CoStar,” he wrote. “How are we going to face the outside world when they criticize us for suppressing data?”

Apparently looking for new ways to highlight the benefits of Seroquel, the company’s Commercial Support Team performed a meta-analysis of a number of other studies. This meta-analysis did not raise Seroquel’s status over Haldol. Instead, the team’s technical document from March 2000 concluded, “In terms of generating positive claims for Seroquel these analyses seem to be somewhat disappointing.”

This analysis came at a very bad time for AstraZeneca. Dr. Charles Schulz at the University of Minnesota was working with the company on preparing a presentation on Seroquel data for the American Psychiatric Association (APA) annual conference in Chicago less than two months later.

In an email from March 2000, Tumas wrote:

The data don’t look good. I don’t know how we can get a paper out of this. My guess is that we all (including Schulz) saw the good stuff, ie the meta analyses of responder rates that showed we were superior to placebo and haloperidol, and then thought that further analyses would be supportive and a paper was in order. What seems to be the case is that we were highlighting only the good stuff and that our own analysis support the ‘view out there’ that we are less effective than haloperidol and our competitors. Once you get a chance to digest this, let’s get together (or teleconference) and discuss where to go from here. We need to do this quickly, because Schulz needs to get a draft ready for APA and he needs any additional analyses we can give him well before then.

Schulz must have received the data he needed, because he presented a summary of the AstraZeneca data as a poster at the May conference, claiming that Seroquel was “significantly superior” to Haldol.

Documents filed as part of the lawsuits against AstraZeneca suggest that AstraZeneca was hoping to market Seroquel, possibly, off-label, to “first-episode” subjects such as those that the CAFE study enrolled. This group would have included Dan Markingson.

The Seroquel Strategy Summary from 2000 said that the company should establish “Seroquel as atypical of choice in first-episode patients – this has a halo effect as these patients are particularly sensitive to EPS and weight gain.” It also listed as an objective broadening “Seroquel use on and off-label. Utilise whole selling team, educational programs to share off-label data.”

In 2007, the American Journal of Psychiatry published the results of the CAFE study, which were positive for Seroquel.

The authors claimed that the CAFE study showed Seroquel to be of “comparable effectiveness” for first-episode patients in comparison to Zyprexa and Risperdal.

Among the 18 “serious adverse events” recorded for the 400 subjects in the study were five suicide attempts, including two completed suicides, both by patients taking Seroquel. One of them was Markingson, although the paper did not name him.

According to the study authors, the suicides occurred “despite the close attention provided in clinical research aftercare programs.”

Author: William Heisel, May 27, 2011

Original article

Copyright: University of Southern California, Annenberg School for Communication & Journalism

Read more articles from William in his Blog William Heisel’s Antidote: Investigating Untold Health Stories

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Meeting at WHO: in a few years MCS and EHS may be included in the International Classification of Diseases (ICD11)

Madrid, May 18, 2011. The National Committee for the Recognition of Multiple Chemical Sensitivity (MCS) and Electromagnetic Hypersensitivity (EHS), on 13rd May 2011, met Dr. Maria Neira, Director of Public Health and Environment of the WHO and other WHO officials. During the meeting, the WHO responsible for the development of the International Classification of Diseases (ICD) admitted that there was a controversy regarding the updating procedure of this classification.

Dr. Neira and her team explained that, up to the release of ICD 10, the National delegations from the Health Ministries were the only one engaged in the revision of the classification, but now the revision is open to public comment and anyone can actively participate and submit scientific evidence to promote new classifications of diseases for the ICD 11, which will be released in 2015. The WHO official also announced that the very first draft of the ICD 11 was going to be released on Monday 17th May.

The WHO created a virtual platform to engage the scientific community and the NGOs in the revision of the ICD 11 and this is supposed to guarantee a full transparency throughout the revision process. This new openness by WHO was applauded by the National Committee for the Recognition of MCS and EHS.

In order to get the inclusion of these two environmental disease in the new classification , the WHO officials pointed out that it is essential to present clear evidence about the diseases: etiology, pathophyisyology, diagnostic tests, etc.

Jaume Cortés, lawyer from the association Colectivo Ronda, explained on behalf of Committee, the evidence given by more than 200 legal compensation sentences won by MCS and EHS patients.

Dr. Julian Marquez, a neurophysiologist with extensive experience in these cases, presented a dossier about the scientific studies on MCS and EHS published in the recent years.

The Committee will actively participate in the platform created by WHO in order to get an ICD code for EHS and MCS, considering that the national versions of ICD 10 in Germany, Austria, Luxembourg and Japan already assigned a code to MCS.

For more information contact Sonia Ortiga: mail environmentalhealthcampaign @ gmail.com and telephone 645803417.

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